KPV 15mg

Size: 15mg
Contents: KPV (15mg)
Form: Lyophilized powder
Purity: >99%
SKU: P-KPV-15

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Alpha melanocyte-stimulating hormone (a-MSH) is also classified as a melanotropin. a-MSH is an endogenous peptide hormone, composed of 13 amino acids, and considered to play a role in metabolic function, as well as other biological processes. Scientists isolated a fragment of this protein hormone and identified its potential biological action, naming it KPV peptide. KPV comprises three amino acids: Lysine, Proline, and Valine.⁽¹⁾ This peptide is a C-terminal fragment of the a-MSH protein hormone, which is considered the primary amino acid sequence in the hormone responsible for its properties.⁽²⁾

A study⁽²⁾ was published in 1989 explaining how the tripeptide was isolated and its biological potential determined. Upon discovering that the COOH terminal peptide in the a-MSH hormone is the primary amino acid messenger sequence, scientists conducted preliminary research to determine if KPV might prevent an excessive increase in vasopermeability and excessive swelling of blood vessels. As a part of the study, scientists isolated the KPV peptide and presented it to experimental mice to determine its potential to mitigate swelling in their ears. After the completion of the study, the researchers reported that the isolated fragment appeared to have inhibited the swelling. KPV's potential anti-inflammatory action may be induced by inactivating the inflammatory pathways.⁽³⁾ It may also possibly inhibit the synthesis and release of the pro-inflammatory cytokine cells in intestinal and immune cells.

Chemical Makeup

Molecular Formula: C₁₆H₃₀N₄O₄
Molecular Weight: 342.43 g/mol
Other Known Titles: MSH (11-13), ACTH(11-13), alpha-MSH(11-13)

Research and Clinical Studies

KPV Peptide and Intestinal Protection

A study⁽⁴⁾ was conducted on murine models to determine the peptide's potential on intestinal inflammation. The experiment was conducted on mice induced with bowel dysfunction. These mice were divided into two groups: one group was given the peptide, and the other was given the placebo. After the study, researchers reported that the peptide mice exhibited reduced inflammatory cells and anti-enzymatic symptoms.

Another study⁽⁴⁾ was conducted on a murine model of inflamed intestines, which involved the exposure of a chemical-induced compound of KPV and a chemical called hyaluronic acid. This chemical-induced KPV compound was given to the mice, with the added hyaluronic acid supplementation, intended to aid targeted delivery of the peptide to specific locations in the intestine. The results observed mitigated swelling in the intestine.